Some versions of HammerDB (e.g. 3.2) may induce imbalanced NUMA utilization with SQL Server.

This can easily be observed with Resource monitor. When NUMA imbalance occurs one of the NUMA nodes will show much larger utilization than the other. E.g.

The cause and fix is well documented on this blog. In short HammerDB issues a short lived connection, for every persistent connection. This causes the SQL Server Round-robin allocation to send all the persistent worker threads to a single NUMA Node! To resolve this issue, simply comment out line #212 in the driver script.

If successful you will immediately see that the NUMA nodes are more balanced. Whether this results in more/better performance will depend on exactly where the bottleneck is.